Work package 1: Oxygen

Oxygen sensing and erythropoietin regulation


Work package leaders: Roland Wenger and Sophie de Seigneux

The kidney is both a major O2 consumer and a main O2 sensing organ. The goal of WP1 is to establish spatial and temporal maps of renal pO2 profiles and O2 fluxes, which allow a better understanding of how O2 distribution and consumption by normal kidney cells is involved in renal O2 sensing and erythropoietin (Epo) regulation in the healthy kidney, and further how O2 redistribution and altered consumption by tubular cells contributes to the anaemia of chronic kidney disease.
In addition, cell intrinsic and extrinsic factors and mechanisms, including the spatially and temporally resolved functions of novel prolyl hydroxylase (PHD) inhibitors, are investigated to elucidate how they interfere with renal O2 sensing under normal and pathological conditions.

To reach these goals, this work package builds upon competence and tools developed during the first phase of the NCCR Kidney.CH, including imaging and computing technologies, novel genetically modified animal models, clinically relevant models of kidney disease, screening tools, and expertise with genome-wide association studies as well as studies on healthy human volunteers.

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