Work package 4: Calcification

Kidney function and biomineralization


Work package leaders: Uyen Huynh-Do and Olivier Devuyst

Calcium and phosphate concentrations in most body fluids are physiologically near supersaturation, such that even small alternations of this balance may impact biomineralization throughout the body. Here, the tubular segments of the kidney play essential roles, by controlling the handling of solutes promoting (calcium, phosphate, oxalate) or inhibiting (magnesium, citrate, uromodulin, fetuin-A) biomineralization. Furthermore, resulting kidney stones and/or nephrocalcinosis are important risk factors for the development of chronic kidney disease (CKD).

The approach of WP4 will integrate the molecular mechanisms of intrarenal calcification at a segmental level, while deciphering the genetic and clinical factors involved. The systematic investigation of the biology of calciprotein particles and their proteinous components should lead to an improved understanding of the basic mechanisms of biomineralization in CKD patients. A better understanding of proteins/metabolites acting as mineralization inhibitors/promoters may help in the design of treatments for patients with kidney disease.


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