Cellular Reprogramming (iREC)
Direct reprogramming can change one cell type into a different one. In most cases, a small set of transcription factors can induce conversion of cell identities. We recently found four factors (EMX2, HNF1B, HNF4A, and PAX8) that are able to turn fibroblasts directly into cells that closely resemble renal tubules.
This platform provides other research groups direct access to reprogrammed cells and the method of reprogramming itself.