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Reference Centres & Technical Platforms

The reference centres and technical platforms support the projects with their know-how, expertise and services in the following areas.

  • Population
Genetics

    Population
    Genetics

  • Imaging &
Microscopy

    Imaging &
    Microscopy

    Johannes Loffing

    Johannes Loffing
    University of Zurich

    Imaging & Microscopy

    This technical platform supports members of NCCR-Kidney.CH and offers services in all aspects of basic and advanced microscopy including sample preparation, tissue processing, histological and image analysis. The platform collaborates closely with the Center for Microscopy and Image Analysis (CMI) of the Medical Faculty of the University of Zurich (Managing Director: Dr. Urs Ziegler). Together with the CMI, the platform provides access to various state-of-the art light- and electron microscopes.
    Special techniques are:

    • automated slide scanning system that allows high-throughput documentation and morphometric analysis of histological specimens
    • high content imaging using state of the art confocal laser scanning microscopes which allows multiparameter imaging of tissue, multiwell plates and semi-automatic screening.
    • system for complex object parametric analysis and sorting (COPAS) that allows large-scale sampling of specific nephron portions for transcriptomic and proteomic analysis as well as for primary cell culture (Miller et al. Am. J. Physiol 291: F236; 2006)
    • laser-microdissection microscope that allows precise tissue sampling from archived histological specimens
    • multiphoton-microscope that allows intravital imaging of organs including the kidney.

    Aside from providing technical infrastructure, the platform advices for planning of histological studies (e.g. type of fixation, antigen-retrieval techniques, troubleshooting, morphometry, image-analysis).

    Contact us

    For further information please contact us:

    • NCCR Kidney.CH

      University of Zurich
      Institute of Physiology
      Building 23, Floor J, Room 04
      Winterthurerstrasse 190
      8057 Zurich / Switzerland

    • info@nccr-kidney.ch
      www.nccr-kidney.ch

      +41 44 635 52 16

  • Computational
Modelling

    Computational
    Modelling

  • Rodent
Phenotyping

    Rodent
    Phenotyping

  • Biochemical
Profiling Platform

    Biochemical
    Profiling Platform

  • Rodent
Transgenesis

    Rodent
    Transgenesis

  • Cellular Repro-
gramming (iREC)

    Cellular Repro-
    gramming (iREC)