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News & Events

See the latest news from the NCCR Kidney.CH below.

The NCCR also regularly organizes educational, networking and outreaching events. Information on upcoming and past events of the NCCR Kidney.CH and other organizers can be found below. Please use the drop-down menu to confine your search.

  • News

    News

    • 12 October 2020

      Electrophysiology Facility launches

      In a joint effort of the Department of Molecular Life Sciences of UZH and the Institute of Anatomy, as well as the Clinic of Endocrinology, Diabetology and Clinical Nutrition from the USZ and the National Center of Competence in Research (NCCR) Kidney.CH, we have launched the Electrophysiology Facility (e-phac).

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    • 9 September 2020

      Cancer drug can rebalance kidney function in a devastating genetic disease

      Researchers at the University of Cambridge and the University of Zurich, including NCCR member Olivier Devuyst, have discovered that a drug newly approved for cancer improves kidney dysfunction in a mouse model of Dent disease 2 and Lowe syndrome.

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    • 2 July 2020

      NCCR member contributes to Science paper on uromodulin

      NCCR scientist & uromodulin expert Olivier Devuyst contributed to this Science paper on how #uromodulin helps fight off urinary tract infections.

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    • 23 June 2020

      NCCR scientists perform high-resolution imaging of calcium ion signaling in kidney cells

      A group of scientists at the University of Zurich, including the NCCR's own Andrew Hall, has shown that it is possible to perform imaging of Ca2+ signals at high resolution in the mouse kidney in vivo.

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    • 27 Mai 2020

      New X-ray contrast agent developed by UZH and NCCR researchers

      Researchers at the universities of Basel and Zurich, including Vartan Kurtcuoglu of the NCCR Kidney.CH, have developed a novel X-ray contrast agent called “XlinCA”.

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2 July 2020

NCCR member contributes to Science paper on uromodulin

NCCR scientist & uromodulin expert Olivier Devuyst contributed to this Science paper on how #uromodulin helps fight off urinary tract infections.

Uromodulin is the most abundant protein in human urine, and it forms filaments that antagonize the adhesion of uropathogens; however, the filament structure and mechanism of protection remain poorly understood. We used cryo–electron tomography to show that the uromodulin filament consists of a zigzag-shaped backbone with laterally protruding arms. N-glycosylation mapping and biophysical assays revealed that uromodulin acts as a multivalent ligand for the bacterial type 1 pilus adhesin, presenting specific epitopes on the regularly spaced arms. Imaging of uromodulin-uropathogen interactions in vitro and in patient urine showed that uromodulin filaments associate with uropathogens and mediate bacterial aggregation, which likely prevents adhesion and allows clearance by micturition. These results provide a framework for understanding uromodulin in urinary tract infections and in its more enigmatic roles in physiology and disease.

See the full Science article here.

Illustration: Uromodulin filaments (in blue) enveloping an E. coli cell.