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See the latest news from the NCCR Kidney.CH below.

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    • 16 December 2020

      NCCR-sponsored IPAHK+ trial gets "POSH"

      An elegant new sub-study examines the effects of potassium supplementation on blood pressure in patients with hypokalemia.

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    • 2 November 2020

      Prof. Sophie de Seigneux wins Stern-Gattiker prize

      The Swiss Academy of Medical Sciences (SAMS) recently announced the winners of the 2020 Stern-Gattiker Prize, a biennial award recognizing outstanding women in academia. The NCCR's own Sophie de Seigneux was one of two women recognized this year.

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    • 12 October 2020

      Electrophysiology Facility launches

      In a joint effort of the Department of Molecular Life Sciences of UZH and the Institute of Anatomy, as well as the Clinic of Endocrinology, Diabetology and Clinical Nutrition from the USZ and the National Center of Competence in Research (NCCR) Kidney.CH, we have launched the Electrophysiology Facility (e-phac).

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    • 9 September 2020

      Cancer drug can rebalance kidney function in a devastating genetic disease

      Researchers at the University of Cambridge and the University of Zurich, including NCCR member Olivier Devuyst, have discovered that a drug newly approved for cancer improves kidney dysfunction in a mouse model of Dent disease 2 and Lowe syndrome.

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    • 2 July 2020

      NCCR member contributes to Science paper on uromodulin

      NCCR scientist & uromodulin expert Olivier Devuyst contributed to this Science paper on how #uromodulin helps fight off urinary tract infections.

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2 July 2020

NCCR member contributes to Science paper on uromodulin

NCCR scientist & uromodulin expert Olivier Devuyst contributed to this Science paper on how #uromodulin helps fight off urinary tract infections.

Uromodulin is the most abundant protein in human urine, and it forms filaments that antagonize the adhesion of uropathogens; however, the filament structure and mechanism of protection remain poorly understood. We used cryo–electron tomography to show that the uromodulin filament consists of a zigzag-shaped backbone with laterally protruding arms. N-glycosylation mapping and biophysical assays revealed that uromodulin acts as a multivalent ligand for the bacterial type 1 pilus adhesin, presenting specific epitopes on the regularly spaced arms. Imaging of uromodulin-uropathogen interactions in vitro and in patient urine showed that uromodulin filaments associate with uropathogens and mediate bacterial aggregation, which likely prevents adhesion and allows clearance by micturition. These results provide a framework for understanding uromodulin in urinary tract infections and in its more enigmatic roles in physiology and disease.

See the full Science article here.

Illustration: Uromodulin filaments (in blue) enveloping an E. coli cell.